WAHLESTEDT, Claes,Liang, Zicai,KOCH, Troels,Elmén, Joacim,Sorensen, Anders,Ørum, Henrik
申请号：
DK09169380
公开号：
DK2141234T3
申请日:
2004.03.22
申请国别(地区):
DK
年份:
2016
代理人:
摘要：
The present invention is directed to double-stranded short interfering (siRNA) analogues comprising locked nucleic acid (LNA) monomers. Such compounds induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). The compounds disclosed herein has improved properties compared to non-modified siRNAs and may, accordingly, be useful as therapeutic agents, e.g., in the treatment of various cancer forms. More particularly, the present invention is directed to siRNA analogues comprising a sense strand and an antisense strand, wherein each strand comprises 12-35 nucleotides and wherein the siRNA analogues comprise at least one locked nucleic acid (LNA) monomer.
