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Subunits of the adenovirus fiber protein and uses thereof as vaccines
专利权人:
Jacob Pitcovski
发明人:
Jacob Pitcovski,Elena Fingerut,Bezalel Gutter,Gilad Gallili,Amnon Michael
申请号:
US12960932
公开号:
US08168750B2
申请日:
2010.12.06
申请国别(地区):
US
年份:
2012
代理人:
摘要:
A nucleic acid sequence encoding a fragment of the adenovirus fiber capsid protein, a DNA construct including a replicable expression vector and at least one heterologous nucleic acid, and recombinant protein including fragment of the adenovirus fiber capsid protein. The fragment comprises the C-terminal knob and part of the shaft domain of the fiber protein of these adenoviruses. The use of recombinant proteins as an active ingredient in vaccinating compositions for conferring to an animal immunity against a pathogenic infection by an adenovirus, and methods for vaccinating a domestic bird against a pathogenic adenoviral infection.
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