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Antibacterial agents from 1,2 Dihydro 3h pyrrolo [1,2-c] - 3-one replaced imidazole
专利权人:
ACTELION PHARMACEUTICALS LTD.
发明人:
申请号:
ARP160102430
公开号:
AR105646A1
申请日:
2016.08.08
申请国别(地区):
AR
年份:
2017
代理人:
摘要:
Compounds used as antimicrobial agents, especially pyrethroids [1,2-c] pyridane derivatives for the treatment of C-negative bacterial infections. 1. Claim 1: compound of formula (1), wherein m is a set of formula (2),(3) And (4) any R1 representing h, when m is a compound of equation (2),R² represents SO₃H, phosphonoxymethyl or the group of formula (5) where R²A represents alkyl C₁₋₄aminoalkyl C₁₋₄,[dialkyl C₂₋₄amino] methyl, {(methyl) [C₂₋₄ alkyl] amino} methyl, [dialkyl C₁₋₄amino] C₂₋₄ alkyl,2. Morfolin-4-il-lease c832131;1. Calcium phosphate c83217c83183248a;phosphonoxymethoxy, 2- (phosphonooxy-C₁₋₄-alkyl) -phenyl, (2- (phosphonooxy) -phenyl) -C₁₋₄-alkyl or [2- (phosphonooxy-C₁₋₄-alkyl) -phenyl] -C₁₋₄-alkyl,Or, when m is a formula compound (3) or (4),R2 represents po832333; h832222;SO₃H, phosphonoxymethyl or the group of formula (6) wherein R²BC represents C₁₋₄alkyl-aminoalkyl C₁₋₄,[dialkyl C₁₋₄amino] C₁₋₄ alkyl,2. Morfolin-4-il-lease c832131;1. Calcium phosphate c83217c83183248a;phosphonoxymethoxy, 2- (phosphonooxy-C₁₋₄-alkyl) -phenyl, (2- (phosphonooxy) -phenyl) -C₁₋₄-alkyl or [2- (phosphonooxy-C₁₋₄-alkyl) -phenyl] -C₁₋₄-alkyl,O R2 for H and R1 for Po 83323; h832222;SO₃H, phosphonoxymethyl or the group of formula (7) wherein R¹A represents C₁₋₄-alkyl-alkyl-C₁₋₄,[dialkyl C₁₋₄amino] C₁₋₄ alkyl,2. Morfolin-4-il-lease c832131;1. Calcium phosphate c83217c83183248a;phosphonoxymethoxy, 2- (phosphonooxy-C₁₋₄-alkyl) -phenyl, (2- (phosphonooxy) -phenyl) -C₁₋₄-alkyl or [2- (phosphonooxy-C₁₋₄-alkyl) -phenyl] -C₁₋₄-alkyl;The understanding of molecules is that molecules always combine their R 2 group with the oxygen atom in their equation group (2) in such a way,(3) And (4);Or the salt of this compoundCompuestos derivados de pirrolo[1,2-c]imidazol útiles como agentes antibacterianos, particularmente para el tratamiento de infecciones provocadas por bacterias Gram-negativas. Reivindicación 1: Un compuesto de la fórmula (1) en donde M es uno de los grupos de fórmula (2), (3)
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