KUDUK, SCOTT D.,库杜克 史考特D,庫杜克 史考特D,BESHORE, DOUGLAS C.,比斯尔 道格拉斯C,比斯爾 道格拉斯C,DI MARCO, CHRISTINA NG,迪 马可 克里斯提纳N G,迪 馬可 克里斯提納N G,GRESHOCK, THOMAS J.,葛沙克 汤玛士J,葛沙克 湯瑪士J
申请号：
TW099115163
公开号：
TWI402264B
申请日:
2010.05.12
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
The present invention is directed to benzoquinazilinone compounds of formula (I)which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimers disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.本發明係關於式(I)之苯并喹唑啉酮化合物,其為M1受體正向異位性調節劑且適用於治療涉及M1受體之疾病,諸如阿茲海默氏症(Alzheimers disease)、精神分裂症、疼痛或睡眠障礙。本發明亦係關於包含該等化合物之醫藥組合物,且係關於該等化合物及組合物用於治療由M1受體介導之疾病的用途。
