A method is provided for production of crystalline idarubicin hydrochloride, the method including the steps of: (i) producing a mixture containing (a) idarubicin hydrochloride, (b) at least one alcohol selected from 1-butanol, 2-butanol, and 1-pentanol, and (c) water and (ii) crystallizing idarubicin hydrochloride from this mixture. A crystalline idarubicin hydrochloride is also provided characterized by a powder x-ray diffraction pattern in which at least reflexes at diffraction angles occur in the following ranges (in 2&Theta): 7.2-7.7 11.7-12.2 16.2-16.7 16.7-17.2 19.6-20.1 19.8-20.3 22.2-22.7, and 22.9-23.4.본 특허 출원은(i) (a) 이다루비신 염산염, (b) 1-부탄올, 2-부탄올 및 1-펜탄올로 이루어진 군에서 선택되는 1 이상의 알콜, 및 (c) 물을 포함하는 혼합물을 제조하는 단계, 및(ii) 이 혼합물로부터 이다루비신 염산염을 결정화하는 단계를 포함하는, 결정성 이다루비신 염산염의 제조 방법에 관한 것이다.
