Methods for delivering a bridge retroperfusion therapy are disclosed such that, after the onset of a stroke or other adverse cerebral event, the brain cells window of viability may be extended and other treatments, including pharmaceutical and neuroprotective therapies, may be more effectively utilized. Kits comprising devices and systems for delivering such retroperfusion and autoretroperfusion methods are also disclosed. In certain embodiments, the kits comprise a catheter and a flow unit configured to adjust the flow rate and pressure of the arterial blood used for perfusion of the venous system.