Yan YANG,Rajiv JANJIKHEL,Niranjan RAO,Antonia PERICLOU,Wattanaporn ABRAMOWITZ,Mahendra G. DEDHIYA,Erhard SEILLER,Bernhard HAUPTMEIER
申请号：
US14452864
公开号：
US20140348932A1
申请日:
2014.08.06
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to an immediate release solid oral dosage form containing 1-aminocyclohexanes, preferably memantine or neramexane, and optionally a pharmaceutically acceptable coating, wherein the active ingredient exhibits dose proportionality and is released at a dissolution rate of more than about 80% within about the first 60 minutes following entry of said form into a use environment. The dosage form is direct compressed and has a hardness within the range of between about 3 and about 40 Kp, exhibits an average Tmax within the range of about 2 to about 8 hours with an active ingredient load within the range of about 2.5 to about 150 mg. The formulation allows for dose-proportional compositions for once daily or b.i.d. dosing, while maintaining a steady average range of Tmax.
