RÉCEPTEURS CD27 CHIMÈRES UTILISÉS POUR REDIRIGER DES LYMPHOCYTES T VERS DES TUMEURS MALIGNES POSITIVES POUR CD70

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专利权人:

Baylor College of Medicine

发明人:

申请号：

EP18154502.1

公开号：

EP3372244A3

申请日:

2011.10.27

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

The present invention concerns methods and compositions related to T cells redirected against CD70 for the immunotherapy of CD70-positive malignancies. In aspects of the invention, T cells that are CD70-specific are employed. In particular aspects, there are T cells expressing a novel molecule that comprises the full-length CD70 receptor (CD27) fused to the zeta signaling domain of the T-cell receptor complex. Such T cells recognized CD70-positive tumor cells and have cytolytic activity against CD70-positive cancer cells.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/