The present invention provides a method of preparing a very slightly soluble drug with solid composition. The method includes the following steps: (a) adding a very slightly soluble drug into an organic solvent and polysorbate to form a first solution (b) adding the first solution into a second solution and a pharmaceutically acceptable excipient, wherein the second solution comprises water or SLS, and a volume ratio of the first solution and the second solution is between 8:1 and 1:1 (c) drying and compressing the mixture in step (b) to form a very slightly soluble drug with solid composition.本發明提供了一種製作難溶藥物固體劑型的方法,包含以下步驟:(1) 將一難溶藥物加入一有機溶液以及聚山梨醇酯中,以形成一溶液一;(2)將該溶液一加入一溶液二以及至少一種醫藥上可接受之賦型劑,其中該溶液二包含水或月桂基硫酸鈉,且該溶液二與該溶液一的體積比率為8:1~1:1;以及(3)將步驟(2)之產物乾燥壓縮,以形成難溶藥物之固體劑型。300‧‧‧步驟302‧‧‧步驟304‧‧‧步驟306‧‧‧步驟
