The anthranilic acid derivative or the salt thereof represented by the general formulawherein R1 and R2 are hydrogen atom, or the like R3 is a phenyl, cycloalkyl or bicyclic heterocyclic group which may be substituted, or the like R4 is a phenyl, cycloalkyl or pyridyl group which may be substituted, or the like X1 is an alkylene or alkenylene group which may be substituted or a bond X2 is the general formula -X3-X4- or -X4-X3-, wherein X3 is a sulfur atom, an imino group or a bond, or the like X4 means an alkylene or alkenylene group which may be substituted or a bond is useful for a remedy such as rheumatoid arthritis, osteoarthritis and carcinoma, because it shows MMP-13 production inhibitory effect.
