PROBLEM TO BE SOLVED: To provide novel polymorphs and pseudopolymorphs of valacyclovir hydrochloride and pharmaceutical compositions containing these.SOLUTION: A method of making valacyclovir hydrochloride in form II, characterized by X-ray diffraction reflection at about 6.6°, 19.0°, 21.5°, 27.4° and 28.5°±0.2°2&theta, further characterized by additional x-ray diffraction reflection at about 9.2°, 15.6°, and 26.3°±0.2° degrees 2&theta, and having a X-ray diffraction pattern shown in the figure having an exothermic peak at about 214° by the thermal analysis, includes a step of slurrying valacyclovir hydrochloride in a solvent selected from isopropyl alcohol, 1-butanol, and ethanol.COPYRIGHT: (C)2012,JPO&INPIT【課題】バラシクロビル塩酸塩の新規の多形及び擬多形体並びこれらを含む医薬組成物の提供。【解決手段】II型のバラシクロビル塩酸塩。【選択図】図3
