Disclosed herein are systems and methods for the automatic re-analysis of genetic testing data. A centralized computing system can analyze genetic testing data and automatically re-analyze the genetic testing data when the centralized computing system is updated. In some embodiments, the centralized computing system can be updated with new or updated software, genetic analysis tools, and/or genetic analysis methods. The genetic testing data can then be re-analyzed using the new or updated software, tools, or methods. The genetic testing data can also be re-analyzed if/when available databases or knowledgebases are updated, such as when a new study or report is published. Based on the re-analysis, a suggested diagnoses and/or treatment plans can be revised.