Addex Pharma S.A.;Ortho-Mcneil-Janssen Pharmaceuticals, Inc.
发明人:
Andres Avelino Trabanco-Suarez,Jose Maria Cid-Nunez
申请号：
BRPI0920354
公开号：
BRPI0920354A2
申请日:
2009.10.15
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
The present invention relates to novel compounds, in particular novel indole and benzomorpholine derivatives according to Formula (I) wherein all radicals are as defined in the application and claims. The compounds according to the invention are positive allosteric modulators of metabotropic receptors&mdash；subtype 2 (&ldquo；mGluR2&rdquo；) which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions as well as to the use of such compounds or compositions for the prevention and treatment of such diseases in which mGluR2 is involved.
