Compounds of formula I which inhibit the activity of anti apoptotic Protein bcl-2, where A1 is n or C (A2)； B1 is H, R1, OR1, SR1, S (OR) R1 is H, among others； D1, R1, OR1, SR1, S (OR) R1, so2r1 among others； E1 is H, R1, OR1, SR1, S (OR) so2r1 R1, R1, C (OR), among others； y1 is H, CN, NO2, C (o) o F, Ci , BR, I, among others； Z1 or Z2 is R27 is R26, R28,R29, R30； Z1A panel rc-z2a and both are absent or are taken together to form ch2ch2 or CH2, z12a； z12a is C2 - C6 alquileno with one or two CH2 units replaced by NH (CH3), N, S, S (OR) or SO2； L1 is a or37 sr37 R37,,, S (or so2r37 R37), C (OR) R37, CO (OR) R37, OC (OC) or37 R37, (OR), nhr37, C (o) NH. C (or nr37 (c), or Nhor37), C (o) nhso2r37, so2nh, so2nhr37 NH (n, c), C (n) and nhr37； Z3 is R38, R39 and R40.Furthermore, this Invention includes compositions containing such compounds and Methods of treatment of diseases during the course there is expression of the anti apoptotic Protein Bcl - 2.Розкриті сполуки, які інгібують активність антиапоптичних Всl-2-білків, композиції, що містять такі сполуки, і способи лікування захворювань, в процесі яких експресується антиапоптичний Всl-2-білок.
