#$%^&*AU2020205271A120200806.pdf#####ABSTRACT Provided herein is a method of pulmonary delivering to a subject at least a first pharmacologically active agent and a second pharmacologically active agent, at least one of which being in at least one plant material； the method is carried out by independently delivering the agents to the subject using a metered dose inhaler device that is configured to vaporize at least a first pre-determined vaporized amount of the first agent and at least a second pre-determined vaporized amount of the second agent upon controllably heating the plant material, wherein heating is effected such that the first pre-determined vaporized amount is delivered to the subject successively, concomitantly and/or at least partially overlapping with the delivery of the second predetermined vaporized amount, and wherein each of the pre-determined vaporized amounts of each of the agents independently induces in the subject at least one pharmacokinetic effect and/or at least one pharmacodynamic effect.7/21 1119 1117 Z-------------- 1 113 Time1 FIG. 11A 1107 Time 1115 1109 Patient data input prescribe Syqe Inhaler Interface s~qe 100 CNS 75 1103 FIG. 11B =25/ SUB 1101V 1101 01 2 3 4 5 6 7 8 9 10 11 12 13 14 atientlID Data of Birth Sx Weight Height Drug Dose r Prescribe Syqe Inhaler Interface sqe 0 nPharmacodynamics CNS ~75 b=25 FIG. 11C Pain 01 2 3 4 5 6 7 8 9 10 11 12 13 14 Hours Patient ID Data of Birth Sex Weight Height Drug Dose interval M F kg c m ID Hr 100234 08/08/68 Male0 86kg] 018OnCAN-1030 4h 0 Prescribe )j
