A compression sleeve configured for a conforming fit to a portion of a wearers body, such as a leg. The compression sleeve includes at least one inflatable bladder. The sleeve has a periphery including at least six edges and is configured to wrap around the wearers leg so that the bladder encircles the limb for applying compression therapy to the limb. The shape of the sleeve conforms to the limb of the wearer and keeps the sleeve in place on the limb.