Wilhelmus Everhardus Hennink,Cornelis Franciscus Van Nostrum,Marinus Jacob Van Steenbergen,Osamu Soga,Cristianne Johanna Ferdinand Rijcken
申请号：
US10593529
公开号：
US08110220B2
申请日:
2005.03.17
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to compositions comprising polymers whose solubility characteristics can be changed by incubation and particularly ploy (hydroxyalkyl (meth) acrylamide mono/di-lactate) interpolymers. Another aspect of this invention is the application of such temperature sensitive polymers as release systems of biologically active compounds. The polymers of the present invention comprise monomers, which have modifiable functionality. The functionality of the monomers can for example be modified by the presence of hydrolysable groups. The modification is effected by the incubation, leading to a change of the water solubility characteristics of the polymer. The polymers used in the present invention contain hydrolysable chemical groups. As a result the polymers solution characteristics, specifically its lower critical solution temperature (LCST), change upon incubation.
