DISPOSITIF ELECTRONIQUE D'ADMINISTRATION DE GOUTTELETTES, EN LIGNE, ACTIONNE PAR LA RESPIRATION, DOTE D'UNE AMPOULE DE FAIBLE VOLUME, ET METHODES D'UTILISATION
HEBRANK, JOHN H.,MAURER, CHRISTOPHER W.,HUNTER, CHARLES ERIC,LI, CHENGJIE,GERMINARIO, LOUIS THOMAS
申请号：
CA3082192
公开号：
CA3082192A1
申请日:
2018.11.08
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
A droplet delivery device with a small volume drug ampoule and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device is configured to facilitate the ejection of small, e.g., single use, volumes of a therapeutic agent. The droplet delivery device includes a housing, a mouthpiece, a small volume drug ampoule, an ejector mechanism, and at least one differential pressure sensor. The delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a plume of droplets having an average ejected particle diameter within the respirable size range, e.g, less than about 5-6 µm, so as to target the pulmonary system of the user. The small volume drug ampoule may include a reservoir which comprises an internal flexible membrane separating two internal volumes, a first background pressure fluid volume and a second drug volume.
