METHODES UTILISANT DES PRODUITS DE RECOMBINAISON LIANT UN ANTIGENE MONOVALENT ET CIBLANT L'HER2

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专利权人:

ZYMEWORKS INC.

发明人:

NG, GORDON YIU KON,WEISSER, NINA E.,WICKMAN, GRANT RAYMOND

申请号：

CA2929834

公开号：

CA2929834A1

申请日:

2014.11.13

申请国别(地区):

CA

年份:

2015

代理人:

摘要：

Provided herein are methods of use and treatment using a first or a first and second monovalent antigen-binding constructs targeting HER2. The monovalent antigen- binding constructs can include at least one antigen-binding polypeptide comprising a heavy chain variable domain, wherein the antigen-bind polypeptide specifically binds HER2； and a heterodimeric Fc, the Fc comprising at least two CH3 sequences, wherein the Fc is coupled, with or without a linker, to the antigen-binding polypeptide.

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中国工程科技知识中心

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http://www.ckcest.cn/home/