ЛУБЕР Джозеф Р. (US),БАНИК Фрэнк Дж. (US),САУДЕН Гарри С. (US),КРИКСУНОВ Лео Б. (US),ШИМЧАК Кристофер И. (US)
申请号：
RU2013118234/15
公开号：
RU2013118234A
申请日:
2011.03.21
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A tablet comprising a first layer and a second layer, wherein: (i) said first layer comprises a pharmaceutically active substance and the composition of said first layer is different from composition of said second layer (ii) the density of said tablet is less than about 0.8 g / cm and (iii) resolution of said tablet in the mouth when placed on the tongue in less than about 30 sekund.2. A tablet according to claim 1, wherein said second layer comprises a pharmaceutically active veschestvo.3. A tablet according to claim 2, wherein said first layer contains the same pharmaceutically active substance that said second sloy.4. A tablet according to claim 1, wherein said first layer dissolves at least twice faster than said second sloy.5. A tablet according to claim 1, wherein the color of said first layer differs from said second color sloya.6. A tablet according to claim 1, wherein the taste of said first layer differs from said second sloya.7 taste. A tablet according to claim 1, comprising a third layer wherein the composition of said third layer is different from composition of said first layer and said second sloya.8. A tablet according to claim 1, wherein said tablet meets the requirements of the lozenge in the mouth, as defined in the project management guidelines for the Food and Drug Administration, published in April 2007 g.9. A tablet according to claim 1, wherein the density is less than about 0.7 g / sm.10. A tablet according to claim 1, wherein said binder comprises polyethylene glycol having an average particle size of less than about 100 mikron.11. A tablet according to claim 1, comprising Me1. Таблетка, содержащая первый слой и второй слой, причем:(i) указанный первый слой содержит фармацевтически активное вещество, и композиция указанного первого слоя отличается от композиции указанного второго слоя(ii) плотность указанной таблетки составляет менее приблизительно 0,8 г/см3 и(iii) рассасывание указанной таблетки в полости рта при помещении на язык зан
