Ryan Shenvi,Jeremy Roach,Yusuke Sasano,Laura Bohn,Cullen Schmid
申请号：
US16622111
公开号：
US20200131162A1
申请日:
2018.06.07
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The invention provides 20-nor-salvinorin A, an analog of the kappa-opioid agonist salvinorin A. The 20-nor-salvinorin A is an active kappa-opioid modulator and can be used for treatment of medical conditions wherein modulation of the kappa-opioid receptor is medically indicated, such as pain, pruritis, depression, or inflammation, or conditions implicating perception and consciousness. 20-nor-salvinorin A can be less additive when used in treatment compared to a mu-opioid receptor agonist, and 20-nor-salvinorin A is more stable in vivo than is parent compound salvinorin A. The invention further provides synthetic intermediates and procedures for preparation of 20-nor-salvinorin A.
