КЭЙЗБИЕ Дэвид С.,РОБИНСОН Симон П.,ПУРОХИТ Аджай,РАДЕКЕ Хайке С.,ЭЗЕР Майкл Т.,ДИШИНО Дуглас Д.
申请号：
RU2012113613
公开号：
RU2012113613A
申请日:
2012.04.09
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A contrast agent containing an image providing fragment and a compound selected from degelin, pyridaben, pyrimidiphene, tebufenpyrad, phenazaquin, degelin analog, pyridaben analog, pyrimidifen analog, tebufenpyrad analog and phenazquine analogue. 2. The contrast agent according to claim 1, having the formula (I), wherein each A is independently selected from O, CHR, S, and NR； B is selected from hydrogen and C-C1-6alkyl； C is selected from hydrogen, C-C1-6alkyl, and a bond with B ； D is selected from hydrogen and C-C1-6alkyl； E is selected from hydrogen and C-C1-6alkyl； or E and D, together with the carbon atom to which they are attached, form a double bond； or E and D, together with the carbon atom to which they are attached, form a cyclopropyl ring； denotes a single or double bond； R, R, R, R, R, R, R and R are each independently selected from hydrogen and C-C1-6alkyl； R and R are each independently selected from hydrogen, C-C1-6 alkyl, halogen, and hydroxyl group； R and R, if present, are independently selected from hydrogen, C-C1-6 alkyl, halogen, and hydroxyl group； or R and R together form an oxo group； or R and R together form an oxo group； or R is O and R is a bond with R； provided that it is a double bond, R and R are absent； R is hydrogen or a hydroxyl group； R is selected from hydrogen and C-C1-6alkyl； or R and R together form an oxo group or = CHR； provided that the compound of formula (I) has at least one fragment providing an image. 3. A contrast agent according to claim 2, characterized in that A is O； B and C are each independently CH or CH F； D and E are each independently CH or CH F； R, R, R, and R are each independently hydrogen or F； and R and R together form an oxo group. 4. The contrast agent according to claim 2, characterized in that1. Контрастный агент, содержащий фрагмент, обеспечивающий изображение, и соединение, выбранное из дегелина, пиридабена, пиримидифена, тебуфенпирада, феназаквина, аналога дегелина, аналога пиридабена, аналога пи
