PROBLEM TO BE SOLVED: To provide methods of the prevention, treatment, recovery, and cure promotion for bone loss in osteoporosis and periodontitis, alveolar bone deficiency after tooth extraction, osteoarthritis, articular cartilage deficiency, adynamic bone disease, chondrodysplasia, hypochondroplasia, osteomalacia, fracture, and the like by the non-invasive systemic exposure or topical exposure of a hydantoin derivative that has high metabolism stability and exerts intensive parathyroid hormone (PTH) like action, and thereby inducing bone and cartilage assimilation.SOLUTION: A pharmaceutical composition for inducing cartilage assimilation comprises a compound represented by formula (1), or a pharmacologically acceptable salt thereof, as an active ingredient. (R1 and R2 are not both H at the same time, and are each independently H, halogen atom or fluorine-substituted/unsubstituted alkyl or alkoxy and R3 and R4 are fluorine-substituted/unsubstituted methyl or R3 and R4 are cyclized together.)SELECTED DRAWING: NoneCOPYRIGHT: (C)2017,JPO&INPIT【課題】高い代謝安定性を有し、強力な副甲状腺ホルモン(PTH)様作用を発揮するヒダントイン誘導体を非侵襲的に全身曝露又は局所暴露させることで骨・軟骨同化作用を誘導させ、骨粗鬆症、歯周病における骨量減少、抜歯後の歯槽骨欠損、変形性関節症、関節軟骨欠損、無形成骨症、軟骨無形成症、軟骨低形成症、骨軟化症、骨折などに対する予防、治療、回復及び治癒促進方法の提供。【解決手段】式(1)で表される化合物又はその薬理学的に許容される塩を有効成分として含む、軟骨同化作用を誘導するための医薬組成物。(R1及びR2は同時に共にHではなく、各々独立にH、ハロゲン原子又はフッ素置換/非置換のアルキル或いはアルコキシ;R3及びR4はフッ素置換/非置換のメチル又はR3とR4とが一緒に環化した基)【選択図】なし
