New 4-amino-4-oxobutanoyl peptides as inhibitors of viral replication农业专利-农业学术服务平台

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New 4-amino-4-oxobutanoyl peptides as inhibitors of viral replication

专利权人:: ACHILLION PHARMACEUTICALS INC

发明人:: ZHANG SUOMING,LIU CUIXIAN,GADHACHANDA VENKAT,KIM HA YOUNG,PHADKE AVINASH,PAIS GODWIN,CHEN DAWEI,LI SHOUMING,HASHIMOTO AKIHIRO,WANG XIANGZHU,DESHPANDE MILIND,AGARWAL ATUL

申请号：: NZ59266809

公开号：: NZ592668A

申请日:: 2009.12.10

申请国别(地区):: NZ

年份:: 2013

代理人:

摘要：: 592668 Disclosed are specific compounds of formula I, wherein said specific compounds are selected from (2S,4R)-1-((S)-3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)-4,4-dimethylpentanoyl)-N-(1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-4-(7-methoxy-2-phenylquinolin-4-yloxy)pyrrolidine-2-carboxamide； (2S,4R)-1-((S)-2-tert-butyl-4-morpholino-4-oxobutanoyl)-N-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-4-(7-methoxy-2-phenylquinolin-4-yloxy)pyrrolidine-2-carboxamide； (3R,5S)-1-((S)-2-tert-butyl-4-oxo-4-(piperidin-1-yl)butanoyl)-5-(1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropylcarbamoyl)pyrrolidin-3-yl 4-fluoroisoindoline-2-carboxylate； (3R,5S)-1-((S)-2-tert-butyl-4-oxo-4-(piperidin-1-yl)butanoyl)-5-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropylcarbamoyl)pyrrolidin-3-yl biphenyl-4-ylcarbamate； (2S,4R)-1-((S)-2-tert-butyl-4-morpholino-4-oxobutanoyl)-N-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-4-(6-methoxy-3-phenylisoquinolin-1-yloxy)pyrrolidine-2-carboxamide； (2S,4R)-1-((2S)-2-tert-butyl-4-(octahydroisoquinolin-2(1H)-yl)-4-oxobutanoyl)-N-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-4-(7-methoxy-2-phenylquinolin-4-yloxy)pyrrolidine-2-carboxamide； (2S,4R)-1-((2S)-2-tert-butyl-4-oxo-4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)butanoyl)-N-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-4-(7-methoxy-2-phenylquinolin-4-yloxy)pyrrolidine-2-carboxamide； (2S,4R)-1-((S)-4-(azepan-1-yl)-2-tert-butyl-4-oxobutanoyl)-N-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-4-(7-methoxy-2-phenylquinolin-4-yloxy)pyrrolidine-2-carboxamide； (2S,4R)-1-((2S)-2-(2-(2-azabicyclo[2.2.1]heptan-2-yl)-2-oxoethyl)-3,3-dimethylbutanoyl)-N-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-4-(7-methoxy-2-phenylquinolin-4-yloxy)pyrrolidine-2-carboxamide； (3R,5S)-1-((S)-2-tert-butyl-4-oxo-4-(piperidin-1-yl)butanoyl)-5-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropylcarbamoyl)pyrrolidi