An inhibiting heart failure disease pharmaceutical composition is provided.The pharmaceutical composition includes:an effective amount of a KMUP-3 amine salt of formula (I)wherein RX contains a carboxylic group donated from one selected from a group consisting of a sodium carboxyl methylcellulose (sodium CMC), a γ-polyglutamic acid derivative, and co-polymer salt RX− is an anion form of the carboxylic group and a pharmaceutically accepted carrier.