The United States of America;as represented by the Secretary;Department of Health Human Services
发明人:
Yoke Peng Loh,Niamh X. Cawley,Saravana Radha Krishna Murthy,Terence K. Lee
申请号：
US14337408
公开号：
US20150031744A1
申请日:
2014.07.22
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention provides a method of determining the prognosis of cancer in a subject. The method comprises (a) obtaining a sample from the subject, (b) analyzing the sample for the expression level of a carboxypeptidase E (CPE) splice variant, and (c) correlating the expression level in the sample with the prognosis of cancer in the subject. The invention further provides a method of diagnosing cancer, methods of treatment, kits for detecting mRNA expression of a CPE-ΔN, and inhibitors of CPE-ΔN and compositions thereof.
