KUHNERT, SVEN,BAHRENBERG, GREGOR,KLESS, ACHIM,SCHRODER, WOLFGANG
申请号:
NZ59562510
公开号:
NZ595625A
申请日:
2010.03.11
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
The invention relates to substituted 2-mercaptoquinoline-3-carboxamides of formula (1) with the substituents being as described in the specification, their effect on the KCNQ2/3 receptor, methods for the production thereof, medicaments containing said compounds, and the use of said compounds for producing medicaments for treatment of pain, epilepsy, urinary incontinence, anxiety states, dependency, mania, bipolar disorders, migraine, cognitive diseases, dystonia-associated dyskinesias and/or urinary incontinence. Examples of compounds of formula (1) include: 2-(Pentylthio)-N-(2-thienylmethyl)-3-quinoline carboxamide, 2-[2-(Phenylsulfonyl)ethylthio]-N-(2-thienylmethyl)-7-(trifluoromethyl)-3-quinoline carboxamide, N-(2-Cyclopentylethyl)-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide, 2-Ethylsulfanyl-4-methyl-N-(tetrahydropyran-2-yl-methyl)-7-(trifluoromethyl)-quinoline-3-carboxamide, 2-Ethylsulfanyl-5-fluoro-N-[(3-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide, 4-Ethyl-2-ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-7-(trifluoromethyl)-quinoline-3-carboxamide.