A duodenum endothelium membrane can be obtained from a biocompatible material by electrostatic spinning. The duodenum endothelium membrane is placed into a duodenum, so as to not only block contact of food with an intestinal mucosae anatomically, but also avoid affection on functions of cells of the intestinal mucosae physiologically. The duodenum endothelium membrane can be obtained by hybrid electrospinning or/and multilayer electrospinning or/and core-shell electrospinning or/and dry process electrospinning, and is a medical appliance which can reduce injury, prevent dropping, avoid being removed and restrain bounce and can be used for treating diabetes mellitus and adiposis.
