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anti-NR10 antibody and use thereof
专利权人:
CHUGAI SEIYAKU KABUSHIKI KAISHA
发明人:
KURAMOCHI, TAICHI,KASUTANI, KEIKO,OHYAMA, SOUHEI,TSUNODA, HIROYUKI,IGAWA, TOMOYUKI,TACHIBANA, TATSUHIKO,SHIRAIWA, HIROTAKE,ESAKI, KEIKO
申请号:
ES09830463
公开号:
ES2552690T3
申请日:
2009.12.04
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
Anti-NR10 antibody which is any one of: (1) an antibody comprising a heavy chain variable region comprising CDR1 of SEQ ID NO: 9, CDR2 of SEQ ID NO: 197 and CDR3 of SEQ ID NO: 184 (H30 , H44) and a variable chain chain region comprising CDR1 of SEQ ID NO: 202, CDR2 of SEQ ID NO: 170 and CDR3 of SEQ ID NO: 193 (L17); (2) an antibody comprising a heavy chain variable region comprising CDR1 of SEQ ID NO: 196, CDR2 of SEQ ID NO: 197 and CDR3 of SEQ ID NO: 184 (H28, H42) and a variable light chain region comprising CDR1 of SEQ ID NO: 202, CDR2 of SEQ ID NO: 170 and CDR3 of SEQ ID NO: 193 (L17); (3) an antibody comprising a heavy chain variable region comprising CDR1 of SEQ ID NO: 176, CDR2 of SEQ ID NO: 197, CDR3 of SEQ ID NO: 184 (H34, H46) and a variable light chain region comprising CDR1 of SEQ ID NO: 202, CDR2 of SEQ ID NO: 170 and CDR3 of SEQ ID NO: 193 (L17); (4) an antibody comprising a heavy chain variable region comprising CDR1 of SEQ ID NO: 9, CDR2 of SEQ ID NO: 198 and CDR3 of SEQ ID NO: 184 (H57, H78) and a variable light chain region comprising CDR1 of SEQ ID NO: 202, CDR2 of SEQ ID NO: 170 and CDR3 of SEQ ID NO: 193 (L17); (5) an antibody comprising a heavy chain variable region comprising CDR1 of SEQ ID NO: 176, CDR2 of SEQ ID NO: 198 and CDR3 of SEQ ID NO: 184 (H71, H92) and a variable light chain region comprising CDR1 of SEQ ID NO: 202, CDR2 of SEQ ID NO: 170 and CDR3 of SEQ ID NO: 193 (L17); and (6) an antibody comprising a heavy chain variable region comprising CDR1 of SEQ ID NO: 9, CDR2 of SEQ ID NO: 199 and CDR3 of SEQ ID NO: 184 (H97, H98) and a variable chain region lightweight comprising CDR1 of SEQ ID NO: 203, CDR2 of SEQ ID NO: 170 and CDR3 of SEQ ID NO: 193 (L50).Anticuerpo anti-NR10 que es uno cualquiera de: (1) un anticuerpo que comprende una región variable de cadena pesada que comprende CDR1 de SEQ ID NO: 9, CDR2 de SEQ ID NO: 197 y CDR3 de SEQ ID NO: 184 (H30, H44) y una región variable de cadenaligera que comprende CDR1 de SEQ ID NO: 202
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