A therapeutic treatment device including: a heat conduction plate including a first major surface and a second major surface opposite to each other and configured to apply heat to a living tissue, with the first major surface kept in contact with the living tissue an electric resistance pattern formed on an insulative substrate and configured to generate heat upon application of power and an adhesive sheet which adheres the second major surface of the heat conduction plate and the electric resistance pattern to each other and is configured to transfer the heat generated by the electric resistance pattern to the heat conduction plate. A method of manufacturing including: forming the electric resistance pattern on the insulative substrate stacking the heat conduction plate, the insulative substrate and the adhesive sheet and joining the heat conduction plate, the adhesive sheet and the insulative substrate, by hot pressing.
