A lipid layer forming composition for topical treatment of psoriasis comprises volatile silicone oil, polar lipid, C2 - C4 aliphatic alcohol, and a pharmacologically effective amount of an agent for the treatment of psoriasis, wherein the silicone oil has a boiling point above 180 °C, in particular above 200 °C. The composition does not comprise polymer silicone. Also disclosed are corresponding methods of treatment and of manufacture of the composition.