A hybrid cucumber designated Macario is disclosed that has moderate resistance to powdery mildew and cucumber mosaic virus, and has resistance to cucumber vein yellowing virus and scab and gummosis. The invention relates to the seeds of hybrid cucumber Macario, to the plants of hybrid cucumber Macario, and to methods for producing a cucumber plant, either inbred or hybrid, by crossing the hybrid Macario with itself or another cucumber plant. The invention further relates to methods for producing a cucumber plant containing in its genetic material one or more transgenes and to the transgenic plants produced by that method and to methods for producing other cucumber lines, cultivars, or hybrids derived from the hybrid cucumber Macario.