The present invention relates to a drug delivery device for dispensing of a predefined dose of a medicinal product, comprising: a housing, a cartridge holder adapted to receive a cartridge containing the medicinal product to be dispensed, the cartridge holder being connectable to the housing, a drive mechanism to be operably engaged with the cartridge for setting and/or dispensing of a predefined dose of the medicinal product, wherein the drive mechanism is axially slidingly supported in the housing for compensating axial clearance between the drive mechanism and the cartridge and wherein the drive mechanism is axially fixable relative to the housing.
