federalnoe gosudarstvennoe byudzhetnoe obrazovatelnoe uchrezhdenie vysshego obrazovaniya "Severo-Zapadnyj gosudarstvennyj meditsinskij universitet im. I.I. Mechnikova" Ministerstva zdravookhraneniya Rossijskoj Federatsii
发明人:
Strelnikova Elena Gennadevna,Bessonova Elena Andreevna,Shafigullina Zulfiya Rifgatovna,Vorokhobina Natalya Vladimirovna,Velikanova Lyudmila Iosifovna,Shustov Sergej Borisovich
申请号：
RU20160152672
公开号：
RU2649801(C1)
申请日:
2016.12.29
申请国别(地区):
俄罗斯
年份:
2018
代理人:
摘要：
FIELD: medicine.SUBSTANCE: invention relates to medicine, namely, endocrinology, and can be used for simultaneous diagnosis of nonclassical forms of congenital adrenal cortex dysfunction (NFD PD) with deficiency of 21-hydroxylase and 11β-hydroxylase. To do this, use the following methods: high performance liquid chromatography (HPLC) and gas chromatography with mass spectrometric detection (GC-MS). When HPLC is performed, blood indices of cortisol (F), cortisone (E), 21-deoxycortisol (21-deoxy-F), 11-dehydrocorticosterone (A), corticosterone (B), 11-deoxycorticosterone (DOC) and 11-deoxycortisol (S). When GC-MS is performed, the urinary excretion of tetrahydrocortisone (THE) is determined, tetrahydrocortisol (THF), allo-THF, tetrahydrocorticosterone (TNB), allo-THB, tetrahydro-11-dehydrocorticosterone (TNA), tetrahydro-11-deoxy-cortisol (THS), hexahydro-11-deoxycortisol (HHS), tetrahydro-11-deoxy-corticosterone (THDOC), androsterone (An), etiocholanolone (Et), 17β-hydroxyandrostenediol (17βdA), dehydroepia
