A METHOD FOR PRODUCING A PHARMACEUTICAL COMPOSITION IN THE FORM OF A TABLET WITH A SLOW-RELEASE, CONTAINING PYRPHENIDONE, AND ITS APPLICATION FOR THE RELEASE OF THE SYMPTOMS OF CHRONIC RENAL COSITIVITY
1. A method for producing a pharmaceutical composition in the form of a sustained release tablet containing 600 mg of pirfenidone, wherein said method comprises the following steps: Stage 1. Pirfenidone and silicon dioxide are sieved through a 30 mesh sieve in a vibratory granulator, and placed in a belt mixer and mixed in within 5 minutes； - Stage 2. Microcrystalline cellulose, low viscosity hydroxypropyl methyl cellulose (HPMC) and high viscosity hydroxypropyl methyl cellulose (HPMC) are sieved through a 30 mesh sieve in a vibrating granulate re, and placed in a belt mixer from stage 1, and stirred for 15 minutes； - Stage 3. Sodium stearyl fumarate is sieved through a 30 mesh sieve in a vibratory granulator, placed in a belt mixer from stage 1, and stirred for 3 minutes； and - Step 4. From the obtained granulate, tablets are formed in a Stokes tabletting machine equipped with elongated punches having the following pressing parameters: average weight: 850 mg ± 5%； stiffness: maximum 10 kgf； fragility: below 1% .2. A pharmaceutical composition in the form of a sustained release tablet containing 600 mg of pirphenidone obtained by the method of claim 1, wherein the sustained release tablets have a quantitative formula: 3. The pharmaceutical composition of claim 2, wherein the sustained release tablets contain another lower concentration of pirfenidone of 100, 200, or 400 mg. The pharmaceutical composition according to claim 2 or 3, wherein the pharmaceutical composition is in the form of a sustained release tablet containing pirfenidone effective to alleviate the symptoms of chronic renal failure�1. Способ получения фармацевтической композиции в форме таблетки с замедленным высвобождением, содержащей 600 мг пирфенидона, где указанный способ включает следующие стадии:- Стадия 1. Пирфенидон и диоксид кремния просеивают через сито 30 меш в вибрационном грануляторе, и помещают в ленточный смеситель и перемешивают в течение 5 минут；- Стадия 2. Микрокристаллическую целлюло
