Pharmaceutical compositions for the oral administration of mesalazine, Methods for preparing Pharmaceutical compositions and therapeutic methods for using them.The compositions comprise formulations of mesalazine Release delayed immediate - and delayed prolonged - release.Claim 1: a Pharmaceutical Product for oral administration of a Single Dose of Nicotinamide to a subjectCharacterized in that it comprises: (a) a Plurality of minicomprimidos delayed Immediate Release comprising a compressed Matrix that includes mesalazine,Enteric coated with a pH dependentWhere the minicomprimidos - Immediate Release mesalazine slow release selectively in the distal ileum； and (b) a Plurality of minicomprimidos delayed release, Extended coMprenden Matrix comprising a compressed with an inner Lining Of mesalazine extended release independent of pH and an enteric coated external pH dependentWhere the minicomprimidos delayed - release mesalazine extended release selectively in the colon where the relative amounts of (a) and (b) in the pharmaceutical dose of UNITARia are such that between 10 and 90% Weight by weight of the nephrotoxicity that is provided in the pharmaceutical dosage unit is present in the minicomprimidos delayed - extended release； and (b).Total and Nicotinamide in the Pharmaceutical Unit dose is between approximately 0.4 and 6 G.Composiciones farmacéuticas para la administración oral de mesalazina, métodos para preparar las composiciones farmacéuticas y métodos terapéuticos para usarlas. Las composiciones comprenden formulaciones de mesalazina de liberación demorada-inmediata y de liberación demorada-prolongada. Reivindicación 1: Un producto farmacéutico de dosis unitaria para la administración oral de nicotinamida a un sujeto, caracterizado porque comprende: (a) una pluralidad de minicomprimidos de liberación retardada-inmediata que comprenden una matriz comprimida que comprende mesalazina, provista de un recubrimiento entérico dependiente del pH, donde los minicompr
