Methods and apparatus for effectuating a lasting change in a neural function of a patient, including via mechanical force on neural tissue, are disclosed. An apparatus in accordance with one embodiment includes an implantable force delivery device that is changeable between a first state in which the force delivery device applies a first mechanical force to neural tissue, and the second state in which the force delivery device applies no mechanical force or a second mechanical force less than the first mechanical force to the neural tissue, while the force delivery device is implanted. An actuator can be coupled to the force delivery device with a communication link to change the state of the force delivery device, and a controller can be operably coupled to the actuator to automatically direct the force delivery device to change repeatedly between the first and second states while the force delivery device is implanted.
