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1. The procedure of making pharmaceutical components in the form of long release tablets containing pyridydan and its application in reducing chronic renal failure, papillary obstruction and human liver fibrosis
专利权人:
CELL THERAPY AND TECHNOLOGY S.A DE C.V
发明人:
ARMENDARIZ BORUNDA JUAN,MAGAÑA CASTRO JOSE AGUSTIN,CERVANTES GUADARRAMA JORGE
申请号:
CO14008053
公开号:
CO6970587A2
申请日:
2014.01.17
申请国别(地区):
CO
年份:
2014
代理人:
摘要:
The instant invention relates to a process for the preparation of a pharmaceutical composition in sustained-release tablet form comprising from 600 milligrams to 2400 milligrams of Pirfenidone (PFD), in such a way that the drug is bioavailable during an extended period of time of 12 hours from its administration. In this way, the anti-fibrotic and anti-inflammatory action of the drug Pirfenidone is optimized. Moreover, the instant invention offers advantages and a higher therapeutic efficacy compared to other pharmaceutical forms of Pirfenidone for oral administration and its therapeutic application in the regression of chronic renal failure secondary to primary glomerulosclerosis; it shows a better activity with regard to the reduction and/or regression of deleterious effects in breast capsular contracture observed after the surgical implantation of breast implants in humans and has an important anti-TNF-± and anti-TGF-²1 action for the treatment of hepatic fibrosis.
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