PURPOSE: A composition for preventing and treating hepatotoxicity diseases containing caryopteris incana extracts or a compound separated from the same is provided to enhance protective effectson hepatic cells. CONSTITUTION: A composition for preventing and treating hepatotoxicity diseases contains caryopteris incana extracts or a compound separated from the same. The caryopteris incana extract is obtained by extracting the caryopteris incana with water, C1-C4 alcohol or a mixed solvent thereof. The alcohol is methanol or ethanol. The caryopteris incana fraction is a fractions obtained by dichloromethane(CH2Cl2), ethyl acetate or butanol. The caryopteris incana extracts are compounds represented by chemical formula 1-10. The hepatotoxicity disease is drug caused liver damage, viral liver damage, hepatitis, liver hardening, liver cancer or hepatic coma. A pharmaceutical composition for preventing and treating the hepatotoxicity diseases includes the compound of the chemical formula 1-10 or salt which is pharmaceutically acceptable.본 발명은 층꽃풀 추출물, 이의 분획물 또는 이로부터 분리된 화합물을 함유하는 간독성 질환 예방 및 치료용 조성물에 관한 것이다.본 발명의 층꽃풀(Caryopterisincana) 추출물, 이의 분획물 및 이로부터 분리된 화합물은 제3급-부틸히드로퍼옥시드(t-BHP, tertiary-butyl hydroperoxide)와 같은 독성 물질에 의하여 간 독성이 유발되었을 때 간세포 보호 효과가 우수하므로 간 질환의 예방 및 치료에 탁월한 효과를 기대할 수 있다.
