Karen Jean Coffman,Paul Galatsis,Michelle Renee Garnsey,Jaclyn Louise Henderson,Bethany Lyn Kormos,Ravi G. Kurumbail,Martin Youngjin Pettersson,Matthew Richard Reese,Antonia Friederike Stepan,Patrick
申请号：
US15262112
公开号：
US10039753B2
申请日:
2016.09.12
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides novel imidazo[4,5-c]quinoline and imidazo[4,5-c][1,5]naphthyridine derivatives of Formula (I), and the pharmaceutically acceptable salts thereofwherein R1, R1a, R1b, R2, R4, R5, R6, X and Z are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising the compounds of Formula (I) and to use of the compounds in the treatment of diseases associated with LRRK2, such as neurodegenerative diseases including Parkinson's disease or Alzheimer's disease, cancer, Crohn's disease or leprosy.
