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AGENTS ANTIRIDES
专利权人:
Pola Chemical Industries Inc.
发明人:
申请号:
EP17151667.7
公开号:
EP3173063B1
申请日:
2009.11.12
申请国别(地区):
EP
年份:
2019
代理人:
摘要:
Provided are anti-wrinkle agents having a novel scaffold that is suitable as components for external skin preparations such as cosmetics. The anti-wrinkle agents comprise compounds represented by general formula (1), stereoisomers thereof, or pharmacologically acceptable salts thereof. Said anti-wrinkle agents have excellent efficacy in improving wrinkles and sagging that are caused by skin aging with increased age or occur as a result of photoaging due to ultraviolet rays exposure. [In the formula, R 1 represents a hydrogen atom or a 1 to 8 carbon straight or branched alkyl group. R 2 represents -SH, -SO 3 H, -S-S-X 1 , -S-X 2 , -SO-X 3 , -SO 2 -X 4 , -SO 2 -NY 1 -X 5 or -SO 2 -NY 2 -Y 3 . X 1 -X 5 independently are hydrogen atoms or 1 to 8 carbon aliphatic hydrocarbon groups or 5 to 12 carbon aromatic moiety wherein carbon atoms may be substituted with heteroatoms. Y 1 to Y 3 independently represent hydrogen atoms or 1 to 8 carbon linear or branched alkyl groups. R 3 represents a hydrogen atom or acyl group having a 1 to 8 carbon straight or branched alkyl chain. R 4 represents a 5 to 12 carbon aromatic group or polycyclic condensed aromatic group that may have unsubstituted or substituted groups. m represents an integer 0-3 and n represents an integer 1 or 2.]
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