PROBLEM TO BE SOLVED: To provide a coated particulate for an orally disintegrating tablet containing a benzimidazole proton pump inhibitor, which has good drug release characteristics and can be produced with a good yield, and to provide an orally disintegrating tablet of a benzimidazole proton pump inhibitor having good storage stability.SOLUTION: The coated particulate is obtained by coating a drug layer containing a benzimidazole proton pump inhibitor and a crospovidone fine powder having an average particle size of 3-10 &mum on a spherical crystalline cellulose particle and then coating an inert interlayer and an enteric coating layer. The orally disintegrating tablet includes the coated particulate.COPYRIGHT: (C)2010,JPO&INPIT【課題】良好な薬物放出特性を有し、かつ収率よく製造しうる、ベンズイミダゾール系プロトンポンプ阻害剤を含有する口腔内崩壊錠用被覆微粒子を提供すること。さらに、保存安定性の良好なベンズイミダゾール系プロトンポンプ阻害剤の口腔内崩壊錠を提供すること。【解決手段】ベンズイミダゾール系プロトンポンプ阻害剤と、平均粒子径3~10μmの微粉状クロスポビドンを含む薬物層を球形結晶セルロース粒子上に被覆した後、不活性な中間層および腸溶皮膜層を被覆して得られる被覆微粒子、および該被覆微粒子を含む口腔内崩壊錠。【選択図】なし
