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Compound accumulating in inflammatory site, diagnostic agent containing the compound in labeled state and its precursor compound for labeling
专利权人:
Hideo Saji
发明人:
Hideo Saji,Hiroyuki Kimura,Masahiro Ono,Ikuya Seki
申请号:
US13434722
公开号:
US09044520B2
申请日:
2012.03.29
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Embodiments of the invention provide a compound accumulating in an inflammatory site, a diagnostic agent containing the compound in labeled state and its precursor compound for labeling. Such a compound accumulating in inflammatory site may be represented by the following formula (1):Z—Y-Leu-Phe-(X)n-DLys(-(DLys)m-HalB)-(DLys)k-NH2  (1)whereinin the formula (1),Z represents a protective group for an amino groupY represents Met or NleX represents a spacer consisting of one or more of amino acid and/or synthetic organic compoundsn represents 1 or 0m represents 1 or 0k represents 1 or 0 andHalB represents a substituted benzoic acid having a radioactive halogen in an aromatic ring.
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