1-(2-AMINO-3-(ALKYL SUBSTITUE)-3H-BENZIMIDAZOLYLMETHYL)-(3-SUBTITUE)-1,3-DIHYDROBENZOIMIDAZOL-2-ONES AYANT UNE ACTIVITE SUR LE VIRUS SYNCYNTIAL RESPIRATOIRE
BONFANTI, JEAN-FRANCOIS,MULLER, PHILIPPE,FORTIN, JEROME MICHEL CLAUDE,DOUBLET, FREDERIC MARC MAURICE
申请号：
CA2612263
公开号：
CA2612263C
申请日:
2006.06.20
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Inhibitors of RSV replication of formula (I) which can be represented byformula (I) the salts and stereochemically isomeric forms thereof, wherein Ris a radical of formula (a) or (b)； Q is hydrogen or C1-6alkyl optionallysubstituted with a heterocycle or Q is C1-6alkyl substituted with both aradical -OR4 and a heterocycle； Alk is C1-6alkanediyl； X is O or S； -a1=a2-a3=a4 - is -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH- or -CH=CH-CH=N-； R1 is Aror a heterocycle； R2 is hydrogen, C1-6alkyl, substituted C1-6alkyl, C3-7cycloalkyl； R3 is hydrogen, C1-6alkyl, cyano, aminocarbonyl, polyhaloC1-6alkyl, C2-6alkenyl or C2-6alkynyl； R4 is hydrogen or C1-6alkyl； Ar is phenylor substituted phenyl； Het is a heterocycle； pharmaceutical compositionscontaining compounds (I) and processes for preparing compounds (I).
