A device for sealing a vessel, in particular a cartridge or a test-tube for accommodating a freeze-dried pharmaceutical product (S), wherein the vessel comprises at its opening end an opening edge and an adjoining longitudinal portion with an evenly formed inner cross section, including a front plunger to be positioned inside the vessel at the longitudinal portion, is characterized in that the front plunger is configured to be positioned in the vessel in a sealing state, in which the front plunger is fully inserted in the vessel, or in an exchange state, in which the front plunger is inserted partly in the vessel and partly protrudes over the opening edge of the vessel, wherein the front plunger comprises sealing means that are configured to seal the inside of the vessel against the outside when the front plunger is positioned in the sealing state, and one or more communicating grooves that are configured to place the inside and outside of the vessel in communication with each other when the front plunger is positioned in the exchange state. Furthermore, a method of manufacturing a sealed vessel is disclosed.一種用以密封容器的裝置，特別是用以裝入經冷凍乾燥的醫藥產物之筒件或試管的容器，其中該容器包含一在其開口端處的開口邊緣及一具有均勻形成的內部截面之毗連的縱部分，該裝置包括一欲定位在該容器內之縱部分處的前端柱塞，其特徵為該前端柱塞係組配為定位在該容器中呈密封狀態，其中該前端柱塞完全塞入該容器中；或呈交換狀態，其中該前端柱塞有部分塞入該容器中及有部分突出在該容器之開口邊緣上，其中該前端柱塞包含一密封工具，其係組配為當該前端柱塞係定位成呈密封狀態時對著外部密封該容器的內部；及一或多個連通槽，其係組配為當該前端柱塞係定位成呈交換狀態時讓該容器的內部與外部安置呈彼此連通。再者，本發明揭示出一種製造密封容器的方法。
