Double-stranded RNA molecules with stability in mammalian body fluid, preparation and application thereof

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专利权人:

Quan Du

发明人:

Quan Du,Zicai Liang

申请号：

US13582936

公开号：

US08846895B2

申请日:

2011.03.29

申请国别(地区):

US

年份:

2014

代理人:

摘要：

The present invention discloses preparation and application of double-stranded RNA molecules stable in mammalian body fluids. The mammalian-body-fluid-stable RNA molecules disclosed in the present invention are comprised of only unmodified nucleotides. For the first time, the present invention discloses the applications of mammalian-body-fluid-stable RNA molecules for immunotherapy and siRNA drug development.

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