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Methods and materials for assessing prostate cancer therapies and compounds
专利权人:
The Regents of the University of California
发明人:
Jung, Michael E.,Ouk, Samedy,Sawyers, Charles L.,Chen, Charlie D.,Welsbie, Derek
申请号:
AU2012203589
公开号:
AU2012203589A1
申请日:
2012.06.20
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
#$%^&*AU2012203589A120120712.pdf#####ABSTRACT A modest (2-5 fold) increase in androgen receptor (AR) mRNA is the only expression change consistently associated with developing resistance to antiandrogen therapy. Increased levels of AR confer resistance to anti-androgens by amplifying signal output from low levels of residual ligand and altering the normal response to antagonists. This invention provides cell based assays for use in the examination of new therapeutic modalities and provides for the design of novel antiandrogen compounds.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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