An antioxidant-promoting composition that increases antioxidant defense potential in a subject is disclosed. The composition contains Bacopa monniera extract comprising a Bacopa monniera active ingredient a Silybum marianum (milk thistle) extract comprising a Silybum marianum active ingredient a Withania somnifera (ashwagandha) extract comprising a Withania somnifera active ingredient a Camellia sinensis (green tea) extract comprising a Camellia sinensis active ingredient a Curcuma longa (turmeric) extract comprising at least one Curcuma longa active ingredient, and optionally a Centella asiatica (Gotu kola) extract a Ginko biloba extract an Aloe vera extract and N-acetyl cysteine. The process for quantifying Nrf2 transcription factor activating potential of the botanical extracts comprising the botanical active ingredients is described.
