A pill crusher is provided, which comprises a base, a stopper, an U-shaped movable pressing plate, a connecting rod and a handle, wherein the stopper is mounted on the base the U-shaped movable pressing plate is sleeved on the outside of the stopper and comprises a pressing plate on one side of the stopper and two side walls connected with the pressing plate and pivotedly connected to the stopper, so that the U-shaped movable pressing plate can rotate relative to the stopper and a V-shaped crushing chamber formed between the pressing plate and the stopper is capable of being closed by pressing and being open the connecting rod is positioned on the other side of the stopper and has a first end pivotedly connected with the stopper and a second end the handle has a first end pivotedly connected with the second end of the connecting rod through a third shaft pin and a pivoting portion pivotedly connected with the two side walls as the handle is pressed down, the angle between the connecting rod and the handle increases and the space of the V-shaped crushing chamber decreases gradually and as the handle is raised up, the angle between the connecting rod and the handle reduces and the space of the V-shaped crushing chamber increases gradually. The pill crusher provided by the present invention has the advantages of labor saving, high efficiency, quietness, convenient maintenance and cleaning and the like.