UNIST(ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY);울산과학기술원
发明人:
KANG, Byoung Heon,강병헌,PARK, Hye Kyung,박혜경,LEE, Changwook,이창욱,KANG, Soosung,강수성,LEE, Ji Hoon,이지훈,HONG, Ki-Bum,홍기범,KIM, Darong,김다롱,LEE, Won Seok,이원석
申请号：
KRKR2017/007907
公开号：
WO2018/079988A1
申请日:
2017.07.21
申请国别(地区):
KR
年份:
2018
代理人:
摘要：
The present invention relates to a compound simultaneously inhibiting a heat shock protein Hsp90 and a Hsp90 homologous protein such as TRAP1 and, more specifically, to: a compound having a structure of the following chemical formula I, and being useful as an inhibitor of Hsp90 and a homologous protein thereof； and an anticancer composition containing the same.La présente invention concerne un composé inhibant simultanément une protéine de choc thermique Hsp90 et une protéine homologue Hsp90 telle que TRAP1 et, plus spécifiquement: un composé qui a une structure de formule chimique I suivante, et qui est utile en tant qu'inhibiteur de Hsp90 et d'une protéine homologue de celle-ci； et une composition anticancéreuse contenant ledit composé.본 발명은 열 충격 단백질 (heat shock protein) Hsp90및 TRAP1과 같은 Hsp90 상동단백질을 동시에 저해하는 화합물에 관한 것으로서, 보다 상세하게는 하기 화학식 I의 구조를 갖는 Hsp90 및 이의 상동단백질 저해제로서 유용한 화합물 및 이를 포함하는 항암용 조성물에 관한 것이다:
